Harrison missed all three practices last week with a bruised left knee, and coach Tony Dungy had said his status would be a gametime decision.
Linebackers Freddy Keiaho (ear) and Tyjuan Hagler (neck) and offensive tackle Tony Ugoh (neck) also were on the inactive list for Indianapolis.
Free safety Eugene Wilson is out for New England with an ankle injury. He was limited in practice Friday after sitting out Wednesday and Thursday.
Reserve linebacker Eric Alexander (knee) also is out for the Patriots.
Patriots rushing leader Sammy Morris was placed on injured reserve Friday, ending his first season with the team.
More from ESPN.com
Former Vikings CB Rhodes to sign with Colts Xavier Rhodes, who became a free agent when the former All-Pro cornerback was released by the Vikings to free up room under the salary cap, has reached a deal with the Colts.
The two best teams in the NFL are squaring off in the RCA Dome in Indianapolis in what will be the best game of the year. This could very well be a preview of the AFC championship game, and the winner will most likely have home-field advantage throughout the AFC playoffs. It could also help us answer the question of whether the Colts' Peyton Manning or the Patriots' Tom Brady is the best quarterback in the NFL.
Expect New England offensive coordinator Josh McDaniels to come out with multiple personnel groupings to spread the field and creating mismatches that Brady can exploit on the back end. Manning must continue to do a great job of reading the defense, adjusting blocking assignments and getting the Colts into a play that has a chance of succeeding against the defensive schemes of Patriots head coach Bill Belichick. The real question is whether defensive coordinators Dean Pees of New England or Ron Meeks of Indianapolis can come up with a way to slow down these high-powered offenses.