ESPN NFL Insider Adam Schefter first reported Boldin was unlikely to play in the game.
He has a knee and ankle injury, but his knee is bothering him considerably more.
Boldin was hurt in this past Sunday's 33-7 loss to the Packers. Although coach Ken Whisenhunt pulled most of his starters early, he left Boldin in the game in the third quarter to help struggling backup quarterback Matt Leinart.
At least for one day, the Cardinals didn't miss Boldin on offense on Sunday. Steve Breaston stepped into Boldin's spot and led Arizona with 125 receiving yards on seven catches in the Cardinals' 51-45 overtime win.
Boldin missed a game earlier this season with a right high ankle sprain, although he complained at the time that he was healthy enough to play.
Information from The Associated Press was used in this report.