INDIANAPOLIS -- Blake Bortles threw for a season-high 330 yards and one touchdown, and T.J. Yeldon scored on a 58-yard run, leading the Jacksonville Jaguars past the Indianapolis Colts 27-0 on Sunday.
By ending a four-game losing streak at Lucas Oil Stadium, the Jaguars (4-3) remained atop the AFC South.
Indy (2-5) lost its second straight, both to division foes.
Bortles and the offense looked good on a day when they played without rookie Leonard Fournette, the NFL's second-leading rusher. Fournette was inactive because of a sprained right ankle.
But the Jags' stifling defense dominated again. While Jacksonville didn't add to its league-leading takeaway total, it matched the single-game franchise record for sacks (10), set in the season opener against Houston.
And Jacksonville got its first shutout since a 41-0 victory over the New York Jets on Oct. 8, 2006.
Indy, strangely, was shut out for the first time since a 41-0 loss to the Jets in a playoff game on Jan. 4, 2003. Its only serious scoring chance was snuffed out with a fourth-down stop at the Jaguars 6-yard line.
It was never even close.
Bortles led Jacksonville to scores on their first two possessions -- getting a 1-yard run from Chris Ivory to cap the first and finishing the second with a nifty 5-yard TD pass to Marcedes Lewis -- for a 14-0 lead. He set up new kicker Josh Lambo for two second-quarter field goals to make it 20-0, and Yeldon's 58-yard TD run late in the third quarter sealed it.
Jaguars: Yeldon had nine carries for 122 yards. Jacksonville had 518 yards in total offense compared with 232 for the Colts. Allen Hurns caught five passes for 101 yards.
Colts: Jacoby Brissett was 22 of 37 for 200 yards. Frank Gore carried nine times for 34 yards, moving within four attempts of passing Barry Sanders (3,062) for No. 6 on the NFL's career list. T.Y. Hilton caught two passes for 27 yards after having one catch in Monday night's loss at Tennessee. The 10 sacks are the most in the Colts' Indianapolis era.
Colts: Indy lost three defensive starters -- cornerback Rashaan Melvin (concussion), inside linebacker John Simon (stinger), safety Malik Hooker (right knee) in the first half. None of the three returned. Starting center Ryan Kelly (hamstring) left in the in the second half and also did not return.
Jaguars: Host Cincinnati on Nov. 5 after getting a bye next week.
Colts: Will try to snap a two-game losing streak when they visit Cincinnati next weekend.
More AP NFL: http://pro32.ap.org and https://twitter.com/AP-NFL
After Cincinnati's defense was unable to stop Ben Roethlisberger and the Pittsburgh Steelers at crunch time last week, the Bengals expect a similar test on Sunday night when they travel to Kansas City for a prime-time matchup against the Chiefs.
Two weeks ago, Derek Anderson was out of football. Last week, he was signed by the Buffalo Bills to be a mentor to rookie quarterback Josh Allen. On Sunday, he will be the Bills' starting quarterback against the Colts in Indianapolis.
The Cleveland Browns, after taking a 38-14 head slap delivered by the Los Angeles Chargers, have reached a crossroad in their first full season with general manager John Dorsey in charge.
The Dallas Cowboys head to the Washington Redskins on Sunday afternoon, setting up an unusually important game for one that falls so early on the schedule.
The Los Angeles Chargers are flying high after their typical slow start to a season and not even traveling more than 5,000 miles for their next home game can dull their emotions.
The unbeaten Los Angeles Rams are on the road again this week to face the 49ers on Sunday in Santa Clara.