NASHVILLE, Tenn. -- Marcus Mariota shuffled around the pocket, carefully protecting a strained left hamstring that already cost him one game this season.
So the quarterback known for his legs showed off his arm.
Mariota threw a 53-yard touchdown pass to Taywan Taylor with 5:29 left , and the Tennessee Titans beat the Indianapolis Colts 36-22 on Monday night to snap an 11-game skid tied for the NFL's longest active losing streak against one team.
Titans coach Mike Mularkey said Mariota followed their instructions, doing whatever he could to lessen the risk of further injury.
"He's as tough as I've been around and made some throws that were, obviously that one to Taywan was a big throw," Mularkey said. "It was a real big throw. I mean he did. He played well."
Mariota was 23 for 32 for a season-high 306 yards. He completed each of his three passes on the drive that ended with Taylor's tiebreaking score.
The Titans (3-3) stopped a two-game slide and moved into a tie for the AFC South lead with Jacksonville and Houston.
Jacoby Brissett tried to rally the Colts (2-4) to a second straight overtime. But Titans linebacker Wesley Woodyard forced Brissett out of bounds shy of the first-down marker on fourth-and-inches with 2:19 left before going toward midfield to celebrate.
Coach Chuck Pagano lost his challenge of the spot and said he wouldn't blame officials.
"Disappointing to say the least," Pagano said. "Got to play 60 minutes. It's a recurring thing I know that."
The Titans were pleased to put their skid against the Colts behind them.
"We feel like every game's a must-win, but this was definitely a must-win, especially with the 11-game streak on the line," Woodyard said. "We came in and answered the call."
Derrick Henry clinched the win for Tennessee with a 72-yard TD run with 47 seconds left. Henry, the 2015 Heisman Trophy winner, finished with a career-high 131 yards on 19 carries. DeMarco Murray also scored.
The Titans looked like the NFL's worst scoring defense in the first half instead of Indianapolis, with Brissett directing the Colts to a 13-9 halftime lead. John Simon then intercepted Mariota's first pass of the third quarter and returned it 26 yards for a TD.
"It's a long season," Mariota said. "You're going to have to play with some sort of nick or ding. I'm just really happy for the guys. I mean they did a great job of putting protection up front."
NFL KICKING RECORD
Tennessee kicker Ryan Succop went 5 for 5 to break the NFL record for most consecutive successful field goals inside of 50 yards. He connected from 48, 32 and 40 yards in the first half and then hit from 23 and 48 yards in the third.
Adam Vinatieri, the Colts' accomplished kicker, got three field goals himself, including a 52-yarder. But he missed an extra point off the left upright.
The Colts' team message got a prime-time audience with outside linebacker Jabaal Sheard wearing a black T-shirt with the message "We Will" over his jersey during the coin toss. On the back were the words "Stand For: Equality Justice Unity Respect Dialogue Opportunity."
The Colts have been wearing these T-shirts during pregame warmups for the last couple of weeks.
A handful of Titans, including defensive lineman Jurrell Casey, raised a fist into the air after the national anthem ended. Wide receiver Rishard Matthews stayed off the field during the anthem for a third straight game.
Titans linebacker Derrick Morgan strained an abdominal muscle. ... Colts cornerback Rashaan Melvin went to the sideline during an injury timeout in the second quarter but returned to the game. ... Colts running back Robert Turbin was escorted to the locker room after a catch and run for 9 yards with 2:30 left. Pagano said Turbin will get an MRI exam on his elbow.
The Colts' 11-game win streak had been tied with Denver for the longest active streak in the NFL. Now Denver stands alone with its 11-game streak over Cleveland, according to the Elias Sports Bureau.
Colts: Host Jacksonville.
Titans: Visit winless Browns.
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From coach Anthony Lynn on down, the Chargers sound pleased by the return of veteran kicker Nick Novak after some early season misfires.
Raiders running back Marshawn Lynch was ejected from Thursday night's game after bumping line judge Julian Mapp in the chest and then grabbing the official by his jersey in the second quarter.
Filling in for injured starter Stephon Gilmore has meant lots of attention for cornerback Johnson Bademosi as he prepares for another Patriots start.
With defensive tackle Corey Liuget's playing status unclear, the Chargers may turn to Jerry Attaochu for the first time in 2017.
While Jed York wouldn't discuss specifics due to a lawsuit filed by Colin Kaepernick, the 49ers' owner did say Thursday that he doesn't think Kaepernick is being blackballed despite the fact that he isn't on an NFL roster.
Steve Young doesn't want Indianapolis to diminish Andrew Luck's role and pleads for the franchise to make the right decision and not rush the quarterback, even if Luck has to sit out for the remainder of the season.