"[He] went through the whole game [with it]," Marrone said Monday. "I don't feel like it's going to be anything. We have time. He's already watching the Miami tape now to get himself ready."
Manuel missed four games earlier this season after he sprained the LCL in his right knee. The rookie also underwent a procedure in August to relieve swelling in his left knee.
The first-round pick completed 71 percent of his passes for 193 yards with two touchdowns and one interception in the Bills' win over the Jaguars.