Including the playoffs, Brady is 200-61 in his career. He ties Peyton Manning, who retired after last season and finished his career with a 200-92 mark.
Asked about the potential milestone leading into Sunday's 22-17 victory over the Jets, Brady said he hadn't thought much about it.
"I love winning games," he said. "I think that's what it comes down to. That's why we all play, and I've just been a part of so many great teams and played with great coaches. Nobody could win a football game by themselves. It takes everybody. ... It means I've been around for a little bit and played with a lot of great players on a lot of great teams."
Now in his 17th season, Brady, 39, hit the milestone while playing through a knee injury. He missed practice on Wednesday and Thursday, which is the first time that has happened for a game he played on a Sunday since late in the 2009 season. That year, Brady was listed on the injury report with rib, right finger and right shoulder injuries.
Sunday marked the 50th win for Brady after facing a fourth-quarter deficit or tie.
"The quarterback's job is to win," coach Bill Belichick said. "He's won a lot. That's good. I'm glad he's our quarterback."
Brady on Sunday also became the fifth player in NFL history to throw for 60,000 yards in a career, joining Manning (71,940), Brett Favre (71,838), Drew Brees (64,180) and Dan Marino (61,361).
Information from The Associated Press was used in this report.