Wolfe found himself in a pile during a running play during a team drill early in practice and stayed down. Trainers helped Wolfe onto a cart, and he was taken to the locker room. Offensive tackle Menelik Watson limped, flexing his right leg following the play.
Wolfe later expressed on Twitter his relief that the injury wasn't as serious as it initially appeared when trainers helped him into the Broncos' complex, as he couldn't put weight on his right leg.
He also posted a picture of his swollen ankle after he had an MRI. In a text to ESPN's Josina Anderson, Wolfe said the injury was a sprain but that he would be ready for the Sept. 11 regular-season opener against the Los Angeles Chargers.
Just a little swelling 😎 pic.twitter.com/iCz1TL7FhE— Derek Wolfe (@Derek_Wolfe95) August 12, 2017
Broncos coach Vance Joseph said after the team's practice that the preliminary exam by the medical staff showed "the first look. It wasn't serious.''
Wolfe suffered a stinger early in training camp and was removed from drills for the remainder of that practice, but he returned to practice quickly in the days that followed.
Like the rest of the Broncos' starting defense, Wolfe didn't get much work in Thursday night's preseason opener in Chicago. He played just three plays in the Broncos' 24-17 victory at Soldier Field.
The starting defense played the opening three plays but was taken out of the game after cornerback Chris Harris Jr. returned an interception 50 yards for a touchdown on the third play of the game.
The Broncos have wrestled with some high-profile injuries in camp. Running back Devontae Booker (left wrist) and linebacker Shane Ray (left wrist) will miss the entire preseason. Defensive end Billy Winn suffered a season-ending knee injury in the win over the Bears; he tore his right ACL.
Denver signed defensive lineman Nelson Adams, who had recently been waived by the Pittsburgh Steelers, when Winn was formally moved to injured reserve.