Here are the most significant NFL players who got banged up in Week 2:
Greg Olsen, TE, Carolina Panthers: Olsen suffered a right foot injury in the first half of the game against Buffalo and limped to the locker room with no shoe on that foot. He was originally declared probable to return, but then declared out at the start of the second half. He was subsequently spotted on crutches, with a walking boot on his right foot. After the game, Olsen revealed to reporters that he had broken his foot and will miss "a lot of games."
How many games? A source told ESPN's Chris Mortensen that Olsen is expected to miss six to eight weeks after undergoing surgery. Furthermore, the Panthers will determine after surgery whether Olsen will be placed on IR with a designation to return.
According to ESPN's Stephania Bell, the location of the fracture will play a big role in Olsen's return timeline.
Marshal Yanda, OG, Baltimore Ravens: Yanda sustained a left ankle injury and was declared questionable to return, before subsequently being declared out. After the game, Ravens head coach John Harbaugh revealed that Yanda has a fractured ankle and is out for the season.
Vic Beasley Jr., DE, Atlanta Falcons: Beasley suffered a hamstring injury in the third quarter, and was declared questionable to return. Though he was not officially downgraded, he did not return for the rest of the game.
On Monday, a league source revealed to ESPN's Vaughan McClure that Beasley has a hamstring tear, and will miss at least a month.
Garett Bolles, OT, Denver Broncos: The Broncos' starting left tackle suffered a left leg injury and was taken off the field on a cart in the third quarter of Sunday's game. Bolles, who was the team's first-round pick in April's draft, appeared to suffer a left leg injury on a 5-yard run by Jamaal Charles, as his leg was pinned to the ground. Following the game, ESPN's Adam Schefter reported that the Broncos fear Bolles has a broken ankle, and he will undergo further testing on Monday. Bolles was seen wearing a walking boot.
On Monday, Broncos coach Vance Joseph told AM 760 that, "We got some good news. It's a bone bruise, and it's week-to-week."
B.J. Goodson, LB, New York Giants: Goodson was designated as out for the Giants' game against the Lions with a leg injury. It wasn't immediately clear how long the injury will keep Goodson sidelined, but it's a significant loss for the team, given that the linebacker had 18 tackles in Week 1. Calvin Munson is Goodson's replacement.
Mike Daniels, DL, Green Bay Packers: Daniels, who has been arguably the Packers' best defensive player this season, injured his hamstring on the opening drive, and was ruled out in the second quarter.
Jordy Nelson, WR, Green Bay Packers: After sustaining a quad injury during the first quarter, Nelson was ruled questionable to return. ESPN's Rob Demovsky notes that the injury is to the same leg on which he had ACL surgery. Though there was never an official update, Nelson did not return to the game.
Ryan Schraeder, OT, Atlanta Falcons: Schraeder sustained a head injury on Devonta Freeman's first-quarter touchdown run, and was later downgraded to out with a concussion. Ty Sambrailo took over at right tackle.
Corey Coleman, WR, Cleveland Browns: Coleman left Sunday's game with 13:15 remaining after falling awkwardly following a collision with Marlon Humphrey. ESPN's Josina Anderson reported Monday that the wideout's hand is broken, which was later announced by head coach Hue Jackson. Coleman suffered a broken hand in Week 2 last season as well, missing six weeks.
Jordan Reed, TE, Washington Redskins: Reed, who sustained a chest injury in the second half, returned to the game after originally being designated as questionable to return. He's considered day to day.
Nolan Carroll, CB, Dallas Cowboys: Carroll has been ruled out with a concussion. Because of the injuries to Orlando Scandrick -- inactive because of a broken hand -- and Awuzie, the Cowboys are down to two corners: Anthony Brown and Jourdan Lewis.
Rob Kelley, RB, Washington Redskins: A rib injury knocked Kelley out of the game against the Rams; his original designation was questionable, but he was later downgraded to out. After the game, Redskins coach Jay Gruden revealed that Kelley has possibly fractured a rib. He's considered day to day.
Joe Barksdale, OT, Los Angeles Chargers: Barksdale was knocked out of the game in the second half, although he did leave the field under his own power. Chris Hairston replaced Barksdale at right tackle.
Eric Reid, S, San Francisco 49ers: Reid sustained a left knee injury away from the play during the second quarter and was examined by the 49ers' medical personnel. He walked off the field under his own power and was deemed questionable to return. He did, in fact, return to the game, but left the game again after a big hit on Seahawks tight end Jimmy Graham. Reid returned again -- and left again, after reinjuring the knee. He remained sidelined thereafter.
On Monday, Niners head coach Kyle Shanahan passed along word that Reid will miss the club's Thursday night game due to an injury to the PCL in his left knee.
Jimmy Graham, TE, Seattle Seahawks: Graham was hit at the end of a play during the first half and fell backward awkwardly over a pile. He walked off under his own power but was taken to the medical tent for further evaluation. Graham returned to the game in the second half.
T.J. Watt, LB, Pittsburgh Steelers: Watt suffered a groin injury in the first half against the Vikings and was originally declared questionable to return before being designated as out. After the game, Watt indicated that he didn't believe the injury was serious but would find out more in the coming days, per ESPN's Jeremy Fowler.
Rob Gronkowski, TE, New England Patriots: Gronkowski headed into the medical tent along the sideline after taking himself out of the game following a third-quarter catch. Gronkowski was slow getting up after the play but walked off the field under his own power, then sat on the bench as multiple members of the medical/athletic training staff surrounded him. Gronk was declared questionable to return with a groin injury, but did not return.
DeShone Kizer, QB, Cleveland Browns: A migraine knocked Kizer out of the Browns' contest vs. the Ravens, and he was declared questionable to return. Kizer completed 6 of 11 passes for 81 yards, but had an interception (on a throw off Duke Johnson Jr.'s hand) and a fumble lost on a sack. Kevin Hogan stepped in to replace him, but Kizer returned with 8:19 left in the third quarter.
Brandon Williams, DT, Baltimore Ravens: A foot injury sidelined Williams against the Browns.
Kwon Alexander, LB, Tampa Bay Buccaneers: Alexander left the game against the Bears with a hamstring injury and did not return. Rookie Kendell Beckwith slid over to Alexander's spot with Adarius Glanton stepping into the strong-side role.
Taywan Taylor, WR, Tennessee Titans: Taylor was injured on punt coverage in the first half of the game against the Jaguars and was seen grabbing his left foot/ankle area. He was attended to on the field and walked off under his own power. He made his return late in the second quarter.
Trey Hendrickson, DE, New Orleans Saints: The rookie defensive end was injured in the first half while tackling Mike Gillislee and was attended to by medical personnel on the field. He then got up and walked slowly to the Saints' sideline before heading back to the locker room for further evaluation. He was declared questionable to return but did not.
Jesse James, TE, Pittsburgh Steelers: James was injured on the first drive of the game for the Steelers' offense and was examined on the sideline. James returned on the Steelers' following possession.
Sam Bradford, QB, Minnesota Vikings: Bradford, who has been dealing with pain, swelling and discomfort in his left knee following Minnesota's Week 1 win over the Saints, was one of seven players the Vikings made inactive on Sunday. Bradford went through warm-ups shortly after 10 a.m. ET, during which he did not do much to test the strength of his left knee. Bradford did some light throwing and dropped back a few times on passes, but he did not run or exhibit much footwork at Heinz Field.
Bradford's left knee is the same one in which doctors repaired his torn ACL in 2013 and again in 2014. Backup Case Keenum will start in his place against Pittsburgh.
On Monday, coach Mike Zimmer said that Bradford could miss anywhere from one to six weeks, and that the QB had twisted his knee during the Week 1 win.
Kevin Johnson, CB, Houston Texans: Johnson, the Texans' 2015 first-round pick, was ruled out with a left knee injury in the third quarter of their 13-9 victory over the Cincinnati Bengals on Thursday night. He was checked out on the field by the Texans' medical staff before walking off the field without any assistance. He had four tackles before his injury. However, a source told ESPN's Adam Schefter that Johnson suffered a sprained MCL and is expected to miss four to six weeks, pending further testing.
Johnathan Joseph, CB, Houston Texans: Joseph injured his shoulder while making a tackle in the first half of Thursday's win over the Bengals, and he did not return to the game. An MRI on Joseph's injured shoulder did not reveal any serious damage; however, further testing will be done.