After the game, coach Hue Jackson said Collins has an injury to his MCL and is being evaluated.
"Jamie has an MCL [injury]. We'll find out more about that as we go," He said. "We just need to find out what degree that is, and then we'll know more as we move through the week."
Collins was injured when he was tackled after an interception by offensive lineman Graham Glasgow. Glasgow grabbed Collins around the shoulders and twisted him to the ground. As he did, Collins' knee was caught under Glasgow's body.
Collins immediately grabbed his knee on the field. He was able to walk to the locker room later in the quarter, but he was ruled out early in the second half.
Collins started the game with 26 tackles. The interception was his first. He missed three games this season with a concussion.
In the offseason, the Browns kept Collins off the free-agent market by signing him to a four-year, $50 million contract. The Browns acquired Collins from the Patriots last season via trade.
In addition, DeShone Kizer left the game for about 10 minutes in the fourth quarter with rib injuries that required an X-ray. They were negative.
"It definitely hurt," Kizer said. "I had no idea. I never had a rib injury like that."
Kizer was injured even though he was wearing a flak jacket. He did not believe that he would miss the next game against Jacksonville.
"You know, get back in, get a little treatment and be ready to go next week," Kizer said.