Wentz, who has led the Eagles to an NFL-best 9-1 record and has 25 touchdown passes with just five interceptions in his second season, has 273,367 votes.
New England Patriots quarterback Tom Brady is second with 239,989, followed by Pittsburgh Steelers running back Le'Veon Bell (227,771), Los Angeles Rams running back Todd Gurley (215,687) and Steelers wide receiver Antonio Brown (215,584) to round out the top five.
Fan balloting will continue until Dec. 14. Players for the all-star game in Orlando, Florida, are chosen via votes from fans, players and coaches with each group counting as a third toward the final total. Players and coaches will vote on Dec. 15.
The Pro Bowl rosters will be announced on Dec. 19.