McCaffrey is officially questionable on the injury report with a shoulder injury suffered in last weekend's road win against the New York Jets. He was limited in practices on Thursday and Friday.
The Panthers and Saints are locked atop the NFC South with 8-3 records, so having McCaffrey will be a significant boost for Carolina.
The former Stanford star leads the team in catches with 59, gaining 468 yards and scoring three touchdowns. He ranks second in rushing with 76 carries for 268 yards and two touchdowns. He has 956 all-purpose yards, including kickoff and punt returns.
Information from ESPN's David Newton was used in this report.