Lee suffered a sprained ankle, but X-rays showed no break, a source told ESPN's Adam Schefter. Lee is scheduled to undergo an MRI on Monday, according to the source.
Lee was injured while blocking on Chris Ivory's 8-yard run in the first quarter but wasn't ruled out until the second half.
Lee, who did not have a catch on Sunday, is the Jaguars' leading receiver with 56 catches for 702 yards and 3 touchdowns.
Jaguars quarterback Blake Bortles relied heavily on rookie receivers in Sunday's victory, which clinched the team's first playoff berth since 2007. Undrafted rookie Keelan Cole had 7 receptions for 186 yards and 1 touchdown. Jaydon Mickens, another undrafted rookie, had 4 catches for 67 yards and 2 touchdowns. Fourth-round pick Dede Westbrook had two catches for 21 yards.