He will serve as the honorary alumni captain for the game.
Cole played 10 seasons with the Eagles at defensive end and linebacker and ranks second all time in franchise history with 85.5 sacks. He played two seasons with the Indianapolis Colts (2015-16) after being released by the Eagles in 2014.
Cole, 35, was selected to two Pro Bowls (2007, '09) with the Eagles after the team selected him in the fifth round (146th overall) of the 2005 NFL draft.
In 12 NFL seasons, he had 617 tackles, 90.5 sacks and 21 forced fumbles.
"As a person playing ball, I'll never be satisfied," Cole told the team's website. "I'm going to move on to the next thing. It was a great career, but it just doesn't stop there. Being successful is never going to stop me. I'm not going to stop being successful. I'm going to go on to the next thing and try to be successful."
Cole currently is a co-host for "Blitz TV Outfitted by Cabela's," a nationally televised hunting show.