Malone signed with the Texans last month after going undrafted out of LSU, but has decided to instead pursue a career outside of the NFL.
Malone played left tackle at LSU for the past two seasons, but missed six games with a knee injury in 2017.
The guard attended Houston's rookie minicamp over the weekend. Though he had said his knee was 100 percent and he was ready to fight for a spot on the Texans' roster, Malone tweeted Monday evening that persisting issues with his knee played a part in his decision.
At the scouting combine, Malone, 6-foot-4, 303 pounds, ran a 5.34 in the 40-yard dash, did 15 repetitions on the bench press, recorded a vertical jump of 29.5 inches and had a broad jump of 103 inches.