The second-year running back missed last week's win against the New England Patriots because of a hamstring injury. He officially is listed as questionable on the injury report.
Fournette participated in every drill during the media-viewing portion of practice on Friday.
"We've been playing a lot of tough games," coach Doug Marrone said Friday. "Players are doing the best job they can to get themselves ready to go, but we played a home opener in New York. We played a home opener here [against the Pats]. Now we've got a divisional opponent.
"When you look at it, a lot of teams are going through the same thing, just trying to keep everybody as healthy as they possibly can."
Information from ESPN's Michael DiRocco was used in this report.