After initially announcing that Michel's return was questionable, the team ruled him out for the game in the third quarter. No update to his injury has been announced.
"It's tough to see a guy like that go down. He's been battling some injuries and been working hard and playing well," running back James White said. "I saw him [after the game]. Just hope for a speedy recovery for him, whatever it happens to be. He'll attack it."
"Losing Sony was tough," quarterback Tom Brady said. "We all hope he's OK. He's doing a great job for us."
Michel was running left when Bears defensive tackle Bilal Nichols twisted him to the ground with force, dislodging the ball.
A first-round draft choice out of Georgia, selected No. 31 overall, Michel appeared to be in considerable pain and required help getting to the sideline. After he received help getting to the medical tent, the club called for a cart to bring Michel to the locker room.
Michel, who was on the injury report as a limited participant in practice because of a knee injury, had elevated to a leading role in recent weeks with running backs Rex Burkhead (concussion, eligible to return) and Jeremy Hill (torn ACL, out for the year) on injured reserve.
Michel missed all four of the team's preseason games and the regular-season opener after undergoing a procedure to drain fluid from his knee.
His absence Sunday left the Patriots with just James White and Kenjon Barner at running back. If Michel's absence is a long-term situation, it will likely force the Patriots into exploring the possibility of signing another player at the position.