Simpson caught three passes for 26 yards as the Bengals stunned the Bills on a last-second field goal.
Simpson sat out the first few plays during a 13-8 loss to San Francisco last week. He'd missed two days of practice leading up to that game while under investigation for a marijuana shipment to his house. Simpson had one catch against the 49ers.
Bills right guard Kraig Urbik, who had been listed as doubtful with a knee injury, was inactive. Chad Rinehart started in his place. Cornerback Drayton Florence replaced Terrence McGee, who has a hamstring injury.
Information from The Associated Press contributed to this report.