Source: Trent Cole has strained calf

The Philadelphia Eagles' beleaguered defense will have to do without its top pass-rusher for the next few weeks.

Defensive end Trent Cole, who has led the Eagles in sacks for four of the past five seasons, has a Grade 2 strain of his right calf that is expected to sideline him until after Philadelphia's Oct. 23 bye week, a source familiar with the injury told ESPN NFL Insider Adam Schefter.

The Eagles' plan for Cole is to have him rest and rehab, and then to re-evaluate the injury during the bye week, the source said.

Eagles coach Andy Reid acknowledged that Cole had a calf strain in his news conference Monday, terming it "fairly significant."

Philadelphia's next two games include road tests against the Buffalo Bills (3-1) and Washington Redskins (3-1).

The two-time Pro Bowl player has three sacks this season for the Eagles, who fell to 1-3 Sunday after blowing a 20-point lead in a 24-23 loss to the San Francisco 49ers.

Cole, who turns 29 on Wednesday, has three seasons of 10 or more sacks and has 60 sacks in his career.

In addition to Cole, defensive tackle Antonio Dixon and left tackle Jason Peters also were injured against the 49ers. Reid said Monday that Dixon likely will miss the remainder of the season with a torn triceps while Peters has a "significant" hamstring injury.