Coach Chan Gailey couldn't put a timetable on Jones' recovery, except to say, "It's not a year, but it's going to be a while."
Jones was carted off from the Bills' sideline late in the first quarter after making a 7-yard catch off a screen pass from Ryan Fitzpatrick.
An undrafted rookie free agent last year, Jones had taken over the Bills' No. 2 receiver spot. He entered the game as the team's third-leading receiver with 14 catches for 149 yards and one touchdown. He left with a pair of catches for 25 yards, including an 18-yarder that set up Buffalo's first score, Fred Jackson's 5-yard run.