Hillis missed his third practice in a row Friday with a hamstring injury and wasn't seen by reporters at the team's training facility all week. Browns coach Pat Shurmur said Hillis, whose contract issue and a sickness that caused him to miss a game last month has been a distraction, was getting treatment with the team's trainers.
Meanwhile, Seahawks running back Marshawn Lynch injured his back in pregame warm-ups and was a surprise inactive.
Lynch, who has rushed for 239 yards and two touchdowns this season, was on the sideline during Seattle's first offensive series. A team spokesman said Lynch hurt his back before the game but provided no other specifics.
Hardesty has dropped six Colt McCoy passes in the past two games, and after he let one over the middle slip through his hands early in Friday's practice, Shurmur hollered "get a new running back in there," and Ogbonnaya took Hardesty's spot.
"He dropped the ball and we don't want him to drop the ball," Shurmur said when asked about the move. "We work on catching. You get what you emphasize and we've worked on him catching the football, that's what's going on."
Browns cornerback Joe Haden was active. He missed last week's game in Oakland with a sprained left knee and missed two days of practice this week. However, he looked fine during warm-ups Sunday, and the Browns announced he will play.
The Browns won 6-3.
Information from The Associated Press was used in this report.