GLENDALE, Ariz. -- Arizona running back Beanie Wells left Sunday's game against Pittsburgh in the second quarter with a right knee sprain.
The third-year pro from Ohio State had 42 yards on 12 carries before leaving for the locker room at the two-minute warning. Wells missed the third game of the season, at Seattle, with a hamstring injury.
Wells' first-half performance had put him at 423 yards rushing for the season, more than he gained in all of 2010 when he was slowed by injuries.
The Cardinals lost 32-20.
Information from The Associated Press contributed to this report.