Addai sat out the winless Colts' loss at Cincinnati last week because of the injury and didn't return to practice until Friday.
Addai finished with two carries for 8 yards and two catches for 11 yards. Addai initially remained on the sideline in uniform, but without his helmet and with his socks rolled down. By the second half, Addai was in street clothes.
Addai entered the game as Indianapolis' leader runner with 249 yards and one touchdown on 56 carries. His replacement, Delone Carter, carried 10 times for 89 yards and Indianapolis' lone TD, but also fumbled.
The Colts scratched starting guard Ryan Diem, who has been slowed by ankle soreness, along with offensive tackle Anthony Costanzo (ankle), rookie defensive tackle Drake Nevis (back) and receiver Anthony Gonzalez (groin) against New Orleans.
New Orleans deactivated defensive end Turk McBride because of a shoulder injury. McBride does not start, but has regularly rotated in throughout the season.
Also inactive for the Saints were defensive end David Thomas (concussion) and right tackle Zach Strief (right knee), both starters who have been sidelined since getting hurt against Houston in Week 3, as well as linebacker Will Herring (hamstring).
Information from The Associated Press contributed to this report.