Brown was limited in practice Friday with a groin injury. Coach Mike Shanahan said Thursday that Brown was unlikely to play.
Brown was hurt in the first half of last week's loss to San Francisco. If he doesn't play, Sean Locklear will start at right tackle.
Safety Oshiomogho Atogwe was also limited with toe and knee injuries. He has missed two of the last three games.
Backup linebacker Keyaron Fox has been ruled out for Sunday with a skin infection in his knee.
Cornerback DeAngelo Hall missed practice after his wife gave birth to twins.