SAN FRANCISCO -- Kevin Kolb was inactive for the Arizona Cardinals for the third straight game with a right foot injury, and was replaced at quarterback by John Skelton against the San Francisco 49ers.
A turf toe and a bruise on the side of his foot will keep Kolb sidelined again Sunday. He tested the injuries briefly in practice this week but complained of pain when he planted to throw or moved around.
Arizona tight end Todd Heap also was inactive with a hamstring injury.
The 49ers are relatively healthy.
Running back Frank Gore's right knee injury and defensive lineman Ray McDonald's hamstring strain had each listed as questionable this week. Both were in the starting lineup as San Francisco rolled to a 23-7 win.
Information from The Associated Press contributed to this report.