Woodson was hurt in the fourth quarter and did not return to the Packers' 12th straight victory without a loss. He will be examined further back in Green Bay this week.
Backup tight end Andrew Quarless left late in the period with a sprained right knee, needing help to get to the sideline. Coach Mike McCarthy termed it "serious."
Green Bay also lost running back James Starks with a sprained ankle. The team did not reveal which ankle.
Giants starting safety Kenny Phillips sprained his left knee with about 4 minutes to go in the first half and did not return. Phillips was injured making a tackle on tight end Jermichael Finley's 23-yard catch that helped set up a Packers touchdown late in the half.
Giants rookie linebacker Spencer Paysinger was the first to go down with a strained hamstring early in the second quarter and was declared out for the rest of the game.