The Bengals put Williams on the injured reserve list Monday. They promoted guard Otis Hudson from the practice squad. Hudson was a fifth-round pick last year.
Williams' injury leaves the Bengals without two starters on the right side of their offensive line. Right tackle Andre Smith missed the game on Sunday with an injured left ankle.
Williams, a 12th-year veteran, has been the Bengals' starting right guard since 2004. He was suspended for the first four games this season for violating the NFL's policy on performance-enhancing substances. He said he took an over-the-counter diuretic that's banned.