Ben Roethlisberger active, starts

SAN FRANCISCO -- Pittsburgh Steelers quarterback Ben Roethlisberger started Monday night's 20-3 loss to the San Francisco 49ers despite being limited in practice this week with a sprained left ankle.

Roethlisberger wore a custom-made ankle brace that stretched up his calf while warming up before Monday night's game at San Francisco. He last missed a start due to injury in 2009.

San Francisco linebacker Patrick Willis was inactive for the second straight game with a right hamstring injury. Receiver Braylon Edwards has been hampered by a surgically repaired right knee and missed his third straight game.

Pittsburgh linebacker James Harrison was serving a one-game suspension for a helmet to facemask hit on Browns quarterback Colt McCoy on Dec. 8, and center Maurkice Pouncey was inactive with a sprained left ankle.

Information from The Associated Press contributed to this report.