Defensive tackle C.J. Mosley stepped on Monroe's left ankle in practice Thursday, and Monroe was wearing a walking boot Friday.
He sat out practice and was listed as questionable for the game.
The Jaguars will be without receiver Cecil Shorts (hamstring). Safety Dwight Lowery (shoulder) and tight end Zach Potter (calf) are doubtful. Fellow safety Dawan Landry missed the last two days of practice because of an illness, but interim coach Mel Tucker expects Landry to play.