The Lions have not ruled out any player on Friday's final injury report, but did list safety Chris Harris as doubtful with a sore back.
Moore has been nursing a left hamstring injury for weeks and had a setback during the Saints' penultimate regular-season game against Atlanta on Dec. 26. He did not play in last Sunday's regular-season finale and did not practice this week.
Casillas, a regular in the linebacker rotation who started last Sunday, aggravated a right knee injury that had sidelined him for the three previous games.
Also listed as out for New Orleans is reserve tight end John Gilmore.