Roos sat out for the third straight day of practice Friday after having his appendix removed Monday. His streak had been second only to Detroit's Jeff Backus among active offensive tackles.
"We're not going to play him. We're not going to take any risks or chances with that," Titans coach Mike Munchak said. "He's feeling pretty good, but he probably needs a good week to rest and he'll be fine next week."
Mike Otto, playing in his first game of the season after being sidelined with a knee problem, says he is ready to make his first start since last season.
"It's an opportunity to go out and play against a good team," Otto said. "I'm looking forward to doing my part to help us do what we need to do to win."
In addition to Roos, four other Titans already have been declared out for this week with injuries -- quarterback Jake Locker (shoulder), cornerback Tommie Campbell (knee), running back Javon Ringer (knee) and linebacker Patrick Bailey (ribs).
Linebacker Colin McCarthy practiced Friday after getting Thursday off to rest his troublesome ankle. He will be listed as questionable, but Munchak indicated that he should be able to play Sunday.
Linebacker Will Witherspoon practiced Friday and is questionable as well with a hamstring injury.
Other Titans players are listed as probable for Sunday and practiced all week include: running back Chris Johnson (ankle), receiver Kenny Britt (knee), tight end Craig Stevens (concussion) and safety Jordan Babineaux (wrist).