Nelson, who had back-to-back 100-yard receiving games, pulled his hamstring in practice Wednesday.
Greg Jennings also was out and is scheduled to have to surgery this week on his injured groin.
Jones led all Packers receivers in yards Sunday with 78 yards on seven catches, while Cobb finished with five receptions for 28 yards and a touchdown
Nelson leads the Packers this season in receptions (40) and receiving yards (532) and has five touchdown catches.
Maurice Jones-Drew missed the game for the Jaguars with a foot injury. Jacksonville's other inactives were cornerback Derek Cox; running back Montell Owens; defensive back Dwight Lowery; wide receiver Laurent Robinson; and defensive tackles D'Anthony Smith and Jeris Pendleton.
Information from The Associated Press was used in this report.