McCoy was taken off the field on a cart after staying down following a 7-yard run with less than 2 minutes left Sunday.
He ran for 45 yards on 15 carries and gained another 67 yards on six catches.
McCoy entered the game with 702 yards rushing on 162 carries this season.
Tight end Brent Celek was checked for a head injury but passed tests and was deemed OK.
The Eagles (3-7) have lost six games in a row.