Woodson has missed Green Bay's past six games due to a broken collarbone. The eight-time Pro Bowler had hoped to return for Sunday's game, but McCarthy said the team's medical staff believed it would be better for Woodson to sit.
McCarthy said that Woodson, 36, is frustrated because he is "ready to play" despite missing Wednesday's practice.
The Packers defeated the Bears 23-10 in the first meeting between the NFC North's top teams on Sep. 13. Woodson recorded one of Green Bay's four interceptions in the game and made disparaging comments about Bears quarterback Jay Cutler in a postgame interview with ESPN.
McCarthy also said that linebacker Clay Matthews, who has missed the past four games with a hamstring injury, is expected to play Sunday.
Although Matthews practiced Wednesday, McCarthy stated that Thursday's practice would be the "toughest" for the three-time Pro Bowler.
McCarthy was not as optimistic regarding Jordy Nelson, admitting that the star receiver will be a "long shot" to play against Chicago. Nelson has been slowed by a hamstring injury since late October and missed Sunday's win against the Detroit Lions.