Bush had wanted to play, but Detroit coach Jim Schwartz and team doctors decided that he would be inactive with the knee injury he suffered last week against Arizona.
"I feel good, man," Bush said after Sunday's 27-20 victory. "Honestly, I could have played today but it was coaches and doctors that decided it was best to sit this one out. Just to not risk any further injury. If it was a playoff game, I would have been in there.
"But just to not risk any further injury and get myself healthy and get ready for a really big divisional game this week."
Bush said he will "100 percent" play next week against the Chicago Bears.
Joique Bell enjoyed a productive game Sunday as Bush's replacement, rushing for 63 yards and a touchdown while hauling in four receptions for 69 yards.
Bush injured his left knee when it collided with the helmet of Cardinals safety Tony Jefferson during his 26-yard catch. He grabbed it immediately, left the game and returned later.