The Indianapolis Colts were bracing for the worst after initial tests by doctors showed that receiver Reggie Wayne suffered a season-ending ACL injury in Sunday night's victory over the Denver Broncos, according to league sources.
One source said it "looks like he's out for the year" while another said the team was hoping the MRI "proves the doctors wrong on the ACL."
Wayne is scheduled to undergo that MRI on Monday.
Colts owner Jim Irsay was hoping for the best through his Twitter account early Monday.
Prayers and much love for #87 Reggie...let's pray his right knee gets miracle news!!!!!! Love that man and pray for good news!!!!!!
— Jim Irsay (@JimIrsay) October 21, 2013
Wayne injured his knee when he tried to come back for an underthrown pass by quarterback Andrew Luck with 7:15 left in the Colts' 39-33 victory over the Broncos (6-1).
The 34-year-old Wayne has played in 189 straight games, the most among active players. The Colts (5-2) have a bye next weekend before playing at Houston on Nov. 3.
Wayne finished Sunday night's game with five catches for 50 yards.
Wayne remained on the ground for several minutes as some of his teammates, including Luck, receiver Darrius Heyward-Bey, safety Antoine Bethea and linebacker Robert Mathis circled around him. With the crowd chanting "Reggie, Reggie, Reggie," Wayne finally got up and made his way to the sideline.
"He's our leader, a vet and just tough to see him go down that way," Bethea said. "Hopefully it's not too serious and he can get back to us."
ESPN.com Colts reporter Mike Wells contributed to this report.