After missing this past Sunday's loss to the New Orleans Saints, Spiller will be re-evaluated Monday or Tuesday, according to Bills coach Doug Marrone.
Spiller was largely ineffective while playing through the injury for three games. He gained just 11 yards on six carries in his last action on Oct. 20.
Meanwhile, Marrone also said Monday that linebacker Manny Lawson, who sat out Sunday with a hamstring injury, has a better chance to play against Kansas City.
"Right before the game, he said he felt really good, like he thought he might be able to go," Marrone said. "That's a good sign."
Wide receiver Stevie Johnson, who was limited in the second half of Sunday's game, has a hip flexor injury, according to Marrone, and will be limited in Wednesday's practice.
Rookie receiver Marquise Goodwin will also be limited on Wednesday. X-rays were negative on an elbow injury that forced Goodwin out late in the game.