Both players were injured in Oakland's 49-20 loss to the Philadelphia Eagles on Sunday.
"Pryor's kind of day to day," Raiders coach Dennis Allen said in his weekly Monday news conference.
"Obviously, with hamstrings, you never know, with Darren. So, probably a little more concern with Darren than there'd be with Terrelle but we'll see how both of those guys are doing in the morning and that will probably dictate what their availability is going to be on Wednesday."
Pryor missed the Raiders' 24-14 loss to Washington on Sept. 29 after suffering a concussion six days earlier in Denver. He has been intercepted seven times in his past three games while completing 53.2 percent of his passes and throwing for 492 yards and one touchdown in those games, against Kansas City, Pittsburgh and the Eagles.
He said after Sunday's game that his knee felt fine.
"It's stable," Pryor said. "I can walk on it, nothing's wobbling.
"That's the first thing they asked, was it wobbling? No."
McFadden, though, missed the Raiders' Oct. 6 win over the San Diego Chargers after straining the hamstring the week prior, against Washington. He has never played more than 13 games in any of his previous five NFL seasons due to injury.
Other players injured in Sunday's game were receivers Juron Criner (shoulder) and Rod Streater (hip), right tackle Matt McCants (toe), place-kicker Sebastian Janikowski (ribs), and linebacker Kaluka Maiava (ribs).
As far as rehabbing players, Allen said left guard/center Andre Gurode (quad) was ahead of right tackle Tony Pashos (hip) and that strong safety Tyvon Branch (ankle) "is probably another week or two away, but we'll see. He's made a lot of progress last week so he's getting closer."
Then there's left tackle Jared Veldheer (left triceps).
"The ramp-up process for him is more getting into condition," Allen said, "so that when he gets cleared for contact, that transition period is relatively short."