The biggest injuries of NFL Week 3

It was a particularly devastating day for 49ers fans, as the team suffered big injuries to multiple key players. Here's the latest on all the major injuries from our NFL Nation reporters, including the prognosis on each player for Week 4 and beyond:

Jimmy Garoppolo, QB, San Francisco 49ers

Garoppolo suffered a left knee injury, which the team feared was a torn ACL on Sunday. Monday those fears were confirmed, and he is lost for the season. The Niners will turn to second-year quarterback C.J. Beathard. -- Nick Wagoner

Calais Campbell, DE, Jacksonville Jaguars

Already dealing with soreness in his right knee, Campbell suffered a minor right ankle injury against the Titans. That meant more work for first-round pick Taven Bryan, who recorded his second tackle of the season. Campbell had two sacks against the Titans and is their best pass rusher so expect them to be extra cautious with him this week. -- Michael DiRocco

Muhammad Wilkerson, DT, Green Bay Packers

Wilkerson suffered what appeared to be a serious left ankle injury and was taken to a local hospital. His season could be over. While Wilkerson is out, the Packers will go with a split between Dean Lowry and Montravius Adams at his spot. -- Rob Demovsky

Marcus Peters and Aqib Talib, CB, Los Angeles Rams

Peters and Talib suffered ankle injuries, the Rams said, and were sidelined on Sunday. Peters left the locker room with a walking boot on his right foot, while Talib left with a walking boot on his left foot. Coach Sean McVay said he was uncertain of the extent of their injuries and whether they'd be available Thursday against the Vikings. -- Lindsey Thiry

A.J. Green, WR, Cincinnati Bengals

Green left in the third quarter with a groin injury and did not return to the game, even though he was never declared out. Green said he landed hard on his hip while trying to catch a pass, and it was like "two bones hit." Green said he should be fine and thinks he'll play next week. -- Katherine Terrell

Evan Engram, TE, New York Giants

Engram left the contest after getting hit low in the second quarter. He said it just "didn't feel right." He had a brace on his knee after the game, and will undergo further tests on Monday. -- Jordan Raanan

Trae Waynes, CB, Minnesota Vikings

Waynes will undergo an MRI Monday after injuring his right ankle on a near interception in the first quarter. Waynes exited the game and did not return. Rookie Mike Hughes entered as his replacement at left cornerback. -- Courtney Cronin

Richard Sherman, CB, San Francisco 49ers

Sherman sustained a calf/heel injury that cost him the majority of the game. Sherman is slated for more tests, but left the locker room with a walking boot on his left foot. -- Nick Wagoner

Ricardo Allen, S, Atlanta Falcons

The Falcons have another major injury concern with starting free safety Allen suffering what appeared to be a significant left leg injury. The team called it a calf injury, but coach Dan Quinn couldn't expand on it after Sunday's overtime loss to the Saints. Monday morning, it was revealed to be a torn Achilles tendon, and Allen's season is over. -- Vaughan McClure

Chris Conte, S, Tampa Bay Buccaneers

Safety Chris Conte aggravated a knee injury he'd been dealing with all week, left the game and did not return. He'd been practicing and playing in a brace all week. Safety Isaiah Johnson also left the game with a shoulder injury after colliding with the wall in the back of the end zone, meaning the Bucs might only have two healthy safeties for Week 4, in Justin Evans and rookie Jordan Whitehead. -- Jenna Laine

Tramaine Brock, CB, Denver Broncos

Brock left the game in the first half with a groin injury and did not return. He received treatment after the game and is expected to miss some practice time. Brock's absence put rookie cornerback Isaac Yiadom in the lineup Sunday and Ravens quarterback Joe Flacco repeatedly went after Yiadome in coverage. -- Jeff Legwold

Dee Ford, OLB, Kansas City Chiefs

The Chiefs lost Ford toward the end of Sunday's game with a strained groin, and he'll have an MRI on Monday to reveal the extent of the injury. Ford has been the Chiefs' most consistent pass rusher this season. They'll turn to rookie Breeland Speaks, a second-round draft pick, as the primary replacement. Speaks has played well against the run in limited playing time, but is not yet in Ford's class as a pass rusher. -- Adam Teicher

Morgan Moses, OT, Washington Redskins

Right tackle Moses exited the game in the first half due to a concussion, and was replaced by Ty Nsekhe. Moses was walking around and talking to teammates in the locker room after the game. Washington has a bye this week, so Moses has extra time to clear concussion protocol before an Oct. 8 game at New Orleans. -- John Keim

Senio Kelemete, OG, Houston Texans

Kelemete, who usually starts at left guard for the Texans, injured his knee during warmups and never played in Sunday's loss to the Giants. If he misses a significant amount, Greg Mancz will fill in at left guard. The Texans already lost right tackle Seantrel Henderson for the season with an ankle injury. -- Sarah Barshop

William Hayes and Andre Branch, DE, Miami Dolphins

Miami lost Hayes and Branch to game-ending knee injuries (left knee for Branch, right for Hayes). 2017 first-round pick Charles Harris stepped up for extra playing time after the two veterans left. Each of those losses will be significant, as defensive line depth was one of this team's biggest strengths. -- Cameron Wolfe

Patrick Robinson, CB, New Orleans Saints

Nickel cornerback Patrick Robinson was carted off the field with a left ankle injury Sunday and did not return. That's a big blow for the Saints' pass defense, which has struggled mightily this season, allowing opposing passers to throw for 345.7 yards per game and 10 touchdowns. -- Mike Triplett

Rodney McLeod, S, Philadelphia Eagles

McLeod left the game against the Colts with a left knee injury and did not return. It looked ugly, as teammate Jalen Mills accidentally laid a direct hit on that left leg while trying to make a play, but McLeod was somewhat upbeat about the injury when speaking to reporters after the game. -- Tim McManus

Tyrod Taylor, QB, Cleveland Browns

After sustaining a concussion during the Browns' Thursday night game against the Jets, Taylor was replaced by Baker Mayfield. Although Taylor is expected to clear concussion protocol in the short term, the Browns are poised to name Mayfield their starting QB on Monday. -- Pat McManamon