Quarterback/wide receiver, Indianapolis Colts
The Colts might be rebuilding, but they sent a message against one of the NFL's best teams. Luck connected with Wayne on a 4-yard touchdown pass with 35 seconds remaining, giving Indianapolis a 30-27, come-from-behind victory over Green Bay. Luck threw for a career-high 363 yards while Wayne set a new career mark with 212 receiving yards on 13 catches.
Quarterback/tight end, Atlanta Falcons
Ageless wonder? Apparently so. The 36-year-old Gonzalez had one of his best games as a Falcon, catching 13 passes for 123 yards and a TD in Atlanta's 24-17 victory at Washington.
Ryan, considered by many to be an early front-runner for MVP, didn't hurt his cause Sunday. He threw for 345 yards and a pair of TDs.
Quarterback, New Orleans Saints
Brees got his record (a TD pass in 48 consecutive games) -- he also led the Saints to their first victory of the season. Brees passed for 370 yards and finished with four TDs as New Orleans outlasted San Diego 31-24. Three of Brees' scoring tosses went to Marques Colston (9 catches, 131 yards).
Quarterback, San Francisco 49ers
Game-manager? Please. Efficiency expert might be a better title for Smith, who was nearly flawless against the Bills' hapless defense (see below). Smith completed 18 of 24 passes for 303 yards and three TDs in San Francisco's 45-3 rout.
Wide receiver, Chicago Bears
Marshall appears to be finding a comfort zone with QB Jay Cutler. Marshall caught 12 passes for 144 yards and a score in the Bears' 41-3 victory at Jacksonville.
Quarterback, N.Y. Giants
Things looked bleak for the Giants early. Good thing for them, Manning knows a thing or two about comebacks. Manning passed for 259 yards and three touchdowns as the Giants rallied from an early 14-0 deficit and defeated winless Cleveland 41-27. All three of Manning's scoring strikes went to Victor Cruz (5 catches, 50 yards).
Running back, N.Y. Giants
Bradshaw fumbled on the Giants' first play from scrimmage. The rest of his day was decidedly better. Bradshaw rushed for a career-high 200 yards on 30 carries (6.7-yard average) and a TD in the Giants' victory.
Running back, New England Patriots
Ridley continues to look like the real deal for New England. Coming off a 106-yard, two-TD performance in Week 4, Ridley rushed for 151 yards and one score in a 31-21 victory over Denver.
Safety, Miami Dolphins
After back-to-back heartbreakers, the Dolphins' fortunes turned on Sunday -- thanks in part to Jones. The third-year safety picked off Andy Dalton's overthrown pass at midfield with 1:22 left, sealing Miami's 17-13 victory over the Bengals.
Quarterback, Philadelphia Eagles
Sure, he was impressive late, but Vick's lackluster first half cost the Eagles in a 16-14 loss at Pittsburgh. Vick lost two fumbles, including one in the Steelers' end zone, and passed for only 70 first-half yards. Vick has now committed 11 turnovers on the season.
Quarterback, Kansas City Chiefs
Have we seen the last of Cassel as the Chiefs' starting QB? Maybe. With many fans calling for his benching, Cassel passed for only 92 yards in Kansas City's 9-6 loss to Baltimore. He lost a fumble at the goal line and threw two interceptions before leaving with a head injury.
Running back, Denver Broncos
McGahee is usually one of the Broncos' most reliable offensive players. That wasn't the case on Sunday. Early in the fourth quarter, McGahee dropped an easy fourth-down pass that would have given Denver a first down. Then, with the Broncos driving late, McGahee lost a fumble deep in Patriots territory.
It keeps getting uglier for the Bills' D. A week after being torched by the Patriots, Buffalo was gashed for 621 total yards against San Francisco. The Bills allowed 310 passing yards, 311 rushing yards and didn't record a sack.
The Browns fizzled after a fast start in the Meadowlands and are 0-5 for the first time since their return season to the NFL in 1999. They have also lost 11 straight dating back to last season. Against the Giants, Cleveland committed three turnovers and allowed 502 total yards.