Samuel was hurt Saturday while working in 7-on-7 drills during the team's first practice in full pads this summer. He had an MRI on the injured right hamstring Sunday.
Samuel signed a six-year, $57 million contract with the Eagles after spending his first five seasons with New England. He missed time during the team's workouts last month with a strained left hamstring.
If Samuel is out for an extended period, the Eagles have depth at the position. Two-time Pro Bowl cornerback Lito Sheppard, who lost his left cornerback spot to Samuel and wanted a trade, would step in.
In other news, two-time Pro Bowl right guard Shawn Andrews remained a no-show at camp. Andrews' absence for "personal reasons" is not excused.