Wayne spent 11 seasons as Manning's teammate and is headed into his second season catching passes from Luck. And he already sees some similarities.
"The way [Luck] approaches practice, I hate to do this, but it's somewhat like a Peyton Manning," Wayne said Tuesday in an interview with NBC Sports Network's "Pro Football Talk." "Even though I hate to compare the two, he takes practice just like it's a game. He knows as well as I do that practice is probably going to be harder than the games because you're going to see it so many different ways. In game time, you may only see it once or twice.
"He gets us in and out of the huddle, he tells us to pick it up, he tells the offensive line, 'Hey, we need to do better here.' He tells the receivers, 'I need you to come out a little higher' or whatever the case may be. So he's on it. Whenever your quarterback is doing that, you know you're in the right direction. So I'm glad to see him doing that."
Manning led the Colts to two Super Bowl appearances, winning Super Bowl XLI, during his 14 seasons with the team. He missed the entire 2011 season with a neck injury.
Luck, the No. 1 overall pick in 2012, led the Colts to an 11-5 record and the playoffs during his rookie season.
But Wayne doesn't believe Luck should be the next Manning or any other quarterback in the league. Luck should just be Andrew Luck.
"What I would much rather Andrew do is build his own legacy, whatever that is," Wayne said in the interview. "Andrew, he can't be a Peyton Manning. He can't be a Tom Brady. He can't be an Aaron Rodgers. Only thing Andrew can do is be Andrew, so whatever your motto is, that's what you need to work on. ... I like what I see.
"Well, actually, I love what I see in him. He's going to be very good. He really is, and as long as we can keep him clean up front and the skill guys continue to make plays for him, he is going to be the face of the NFL soon."
The comparison will come up again Oct. 20 when Manning and the Denver Broncos visit Lucas Oil Stadium to take on his former team.