| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Brett Favre |
1. Brett Favre, QB | GB | L 27-20 vs. CHI | 29 | 40 | 322 | 1 | 2 | 1 | 0 | 83.5 |
| 2. Tony Romo, QB | DAL | W 25-24 at BUF | 29 | 50 | 309 | 2 | 5 | 0 | 1 | 49.9 | |
| 3. Matt Schaub, QB | HOU | W 22-19 vs. MIA | 20 | 34 | 294 | 0 | 1 | 2 | 1 | 74.9 | |
| 4. Derek Anderson, QB | CLE | L 34-17 at NE | 22 | 43 | 287 | 2 | 3 | 3 | 0 | 59.0 | |
| 5. Philip Rivers, QB | LAC | W 41-3 at DEN | 13 | 18 | 270 | 2 | 0 | 0 | 0 | 151.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Michael Turner |
1. Michael Turner, RB | LAC | W 41-3 at DEN | 10 | 147 | 14.7 | 1 | 74 | 0 | |
| 2. Kenton Keith, RB | IND | W 33-14 vs. TB | 28 | 121 | 4.3 | 2 | 22 | 0 | ||
| 3. Ronnie Brown, RB | MIA | L 22-19 at HOU | 23 | 114 | 5.0 | 1 | 22 | 0 | ||
| 4. Brian Leonard, RB | LAR | L 34-31 vs. ARI | 18 | 102 | 5.7 | 0 | 31 | 0 | ||
| 5. Sammy Morris, RB | NE | W 34-17 vs. CLE | 21 | 102 | 4.9 | 0 | 13 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Larry Fitzgerald |
1. Larry Fitzgerald, WR | ARI | W 34-31 at LAR | 9 | 136 | 15.1 | 1 | 34 | 0 | |
| 2. Plaxico Burress, WR | NYG | W 35-24 vs. NYJ | 5 | 124 | 24.8 | 1 | 53 | 0 | ||
| 3. Antonio Gates, TE | LAC | W 41-3 at DEN | 7 | 113 | 16.1 | 1 | 34 | 0 | ||
| 4. Braylon Edwards, WR | CLE | L 34-17 at NE | 6 | 110 | 18.3 | 0 | 36 | 0 | ||
| 5. Benjamin Watson, TE | NE | W 34-17 vs. CLE | 6 | 107 | 17.8 | 2 | 35 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Lance Briggs |
1. Lance Briggs, LB | CHI | W 27-20 at GB | 16 | 0 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Karlos Dansby, LB | ARI | W 34-31 at LAR | 14 | 1 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Michael Boley, LB | ATL | L 20-13 at TEN | 11 | 4 | 15 | 0.0 | 0 | 1 | 0 | |
| 4. Will Witherspoon, LB | LAR | L 34-31 vs. ARI | 11 | 3 | 14 | 1.0 | 1 | 0 | 0 | |
| 5. D'Qwell Jackson, LB | CLE | L 34-17 at NE | 9 | 5 | 14 | 0.0 | 0 | 0 | 0 | |