| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Eli Manning |
1. Eli Manning, QB | NYG | W 41-34 vs. TB | 31 | 51 | 510 | 3 | 3 | 0 | 0 | 89.5 |
| 2. Carson Palmer, QB | OAK | L 35-13 at MIA | 24 | 48 | 373 | 1 | 1 | 0 | 0 | 74.4 | |
| 3. Mike Vick, QB | PHI | W 24-23 vs. BAL | 23 | 32 | 371 | 1 | 2 | 2 | 1 | 94.7 | |
| 4. Drew Brees, QB | NO | L 35-27 at CAR | 31 | 49 | 325 | 1 | 2 | 1 | 0 | 72.2 | |
| 5. Brandon Weeden, QB | CLE | L 34-27 at CIN | 26 | 37 | 322 | 2 | 0 | 2 | 0 | 114.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Reggie Bush |
1. Reggie Bush, RB | MIA | W 35-13 vs. OAK | 26 | 172 | 6.6 | 2 | 65 | 0 | |
| 2. C.J. Spiller, RB | BUF | W 35-17 vs. KC | 15 | 123 | 8.2 | 2 | 38 | 0 | ||
| 3. Marshawn Lynch, RB | SEA | W 27-7 vs. DAL | 26 | 122 | 4.7 | 1 | 36 | 0 | ||
| 4. Willis McGahee, RB | DEN | L 27-21 at ATL | 22 | 113 | 5.1 | 2 | 31 | 0 | ||
| 5. Pierre Thomas, RB | NO | L 35-27 at CAR | 9 | 110 | 12.2 | 0 | 48 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Hakeem Nicks |
1. Hakeem Nicks, WR | NYG | W 41-34 vs. TB | 10 | 199 | 19.9 | 1 | 50 | 0 | |
| 2. Victor Cruz, WR | NYG | W 41-34 vs. TB | 11 | 179 | 16.3 | 1 | 80 | 0 | ||
| 3. Danny Amendola, WR | LA | W 31-28 vs. WSH | 15 | 160 | 10.7 | 1 | 56 | 1 | ||
| 4. Brent Celek, TE | PHI | W 24-23 vs. BAL | 8 | 157 | 19.6 | 0 | 28 | 0 | ||
| 5. Darren Sproles, RB | NO | L 35-27 at CAR | 13 | 128 | 9.8 | 0 | 25 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Michael Griffin |
1. Michael Griffin, S | TEN | L 38-10 at SD | 16 | 2 | 18 | 0.0 | 1 | 0 | 0 |
| 2. Sean Lee, LB | DAL | L 27-7 at SEA | 4 | 10 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Mason Foster, LB | TB | L 41-34 at NYG | 12 | 1 | 13 | 0.0 | 0 | 1 | 0 | |
| 4. Russell Allen, LB | JAX | L 27-7 vs. HOU | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Daryl Washington, LB | ARI | W 20-18 at NE | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |