Ladd has missed 16 games after injuring his ankle Oct. 6 at Washington. He had one goal in three games before he was hurt.
Cole was placed on injured reserve retroactive to Tuesday. He missed the Hurricanes' 6-1 loss at Tampa Bay on Wednesday after injuring his neck two days earlier in a 4-3 win at Florida. He is eligible to return Nov. 21 when Carolina is to host Philadelphia.