After his first full-contact practice Tuesday, Matthews said he was "ready to go," but coach Mike Babcock said he would be evaluated Wednesday morning by the team's medical staff.
Matthews was injured Oct. 27 against the Winnipeg Jets and was placed on injured reserve two days later. He was hurt after being on the receiving end of a shoulder-to-shoulder hit from Winnipeg defenseman Jacob Trouba.
Matthews missed 20 games last season, including 10 after separating his right shoulder. He said that this injury is similar but to the opposite shoulder.
Matthews has 10 goals and 6 assists in 11 games this season.
ESPN's Emily Kaplan contributed to this report