St. Louis general manager Doug Armstrong announced Bortuzzo's $4.125 million contract extension Saturday. Bortuzzo is now signed through the 2021-22 season.
"I believe in what's going on here, the people in place and the guys in this room," Bortuzzo said. "I'm very comfortable here, and I'm happy to get [the deal] done."
Bortuzzo, 29, has a goal and two assists in 12 games this season, his fifth with the Blues. He missed the season opener after being suspended and missed time with a lower-body injury.
The Thunder Bay, Ontario, native has skated in 288 regular-season and 23 playoff games with the Pittsburgh Penguins and Blues. He has 13 goals and 32 assists in regular-season play.
The Associated Press contributed to this report.