Duchene was hurt in the third period against Florida on Saturday. He is the team's leading scorer with 12 goals and eight assists.
Colorado coach Patrick Roy said after practice on Monday that "when you lose Duchene and Tanguay, it creates a hole. You don't replace guys like this. At the same time, it's an opportunity for others."
The Avalanche have cooled off since a franchise-best 14-2 start. They've dropped three straight heading into a game against the Chicago Blackhawks on Tuesday.