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Napoli substitute Arkadiusz Milik scored with a sublime volley after coming off the bench to snatch a late and precious 2-1 win at Atalanta.
Inter Milan's run of seven successive league wins was abruptly ended on Sunday when they were crushed 4-1 at Atalanta in rain-sodden conditions.
Milan made a perfect start and took the lead in the second minute with the first real attack of the game, Gonzalo Higuain scoring.
The 19-year-old is the second youngest player from Europe's major leagues to have contributed to six goals or more in all competitions this term.
Comeback specialist Kostas Manolas scored the equaliser for Roma in a 3-3 draw with Atalanta in Serie A on Monday.
A team-by-team guide to the new Serie A season as Cristiano Ronaldo makes the move to the Italian top flight.
Atalanta have signed midfielder Mario Pasalic on loan from Premier League side Chelsea, the Serie A club said on Wednesday.
AC Milan have been excluded from playing in UEFA competitions for the next two seasons in which they qualify for breaching UEFA's FFP rules.