Ayo Saka struck a late winner to extend Lobi Stars' lead to six points, while the ninth Oriental Derby of the season failed to ignite.
2018 ScheduleAll times ET
Title favourites Akwa United, Plateau United and Kano Pillars maintained their early season lead by scoring a combined 11 goals in a frantic match-day
Plateau United failed to capitalise on MFM's slip up, while Enugu Rangers made it three wins on the trot.
League leaders Plateau United suffered a shock defeat on a day when all 10 home teams walked away with three points.
Plateau United and MFM maintained their fight for Nigerian Professional Football League honours on Sunday, but Akwa United lost further ground.
Plateau United maintained their five-point lead at the top of the standings, while Akwa United kept the pressure on the league leaders.
Nigeria league leaders Plateau United were the big winners on match-day 21, while champions Enugu Rangers suffered another heavy defeat.
Midweek games return on Wednesday in the NPFL, and based on fixtures and form, fans shouldn't expect radical changes at the top of the standings.
It won't be long before NPFL followers run out of adjectives to describe 19-year-old striker Stephen Odey following his brace against leaders Plateau.
El Kanemi win 20th straight at home, Akwa United continue to rise up the table after disastrous start headline Nigerian Premier League Matchday 13.