Manchester United's troubles away from home in Europe continued in a 2-1 defeat at Fenerbahce in the Europa League as Paul Pogba limped off injured.
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Manchester United laboured to a 1-0 Europa League victory over Zorya Luhansk at Old Trafford as Zlatan Ibrahimovic headed home in the second half.
Chelsea's preseason opener -- and Antonio Conte's first game as manager -- ended in a 2-0 defeat at Rapid Vienna.
Chelsea XI: Begovic, Ivanovic, Djilobodji, Terry, Baba Rahman, Mikel, Matic, Loftus-Cheek, Moses, Willian, Diego Costa
Valencia coach Gary Neville said he aimed to stretch his team's winning run to four in a row in Thursday's Europa League round-of-32 second leg.
Gary Neville claimed he would not be celebrating despite hailing his best night as Valencia boss.
Under-fire Valencia boss Gary Neville enjoyed the perfect 41st birthday as his side thrashed Rapid Vienna 6-0 in the first leg of their last-32 tie.
Valencia host Rapid Vienna in the Europa League knockout stage, live on ESPN3
Ukraine's Shakhtar Donetsk overcame a rocky start to qualify for the Champions League group stage Tuesday, drawing 2-2 with Austrian side Rapid Vienna
Valencia advanced to the Champions League group stage on Monday by holding off Monaco, while Celtic crashed out after losing at Malmo on Tuesday.
Manchester United have been drawn against Club Brugge in the Champions League playoffs.
Rapid Vienna have advanced to the final qualifying round of the Champions League with a shock 3-2 win over Ajax in Amsterdam, a 5-4 aggregate victory.
The draw for the third qualifying round of the Champions League and some of the bigger clubs join the competition.
Manchester United could face a tricky Champions League playoff against the likes of CSKA Moscow, Lazio, Monaco or Sporting Lisbon in August.
Tottenham came from behind to take a 2-1 win in the first leg of their Europa League qualifying play-off against AEL Limassol.